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“As an athlete, pain is part of the job. I'm grateful my doctor prescribed me JOURNAVX after my surgeries.”

LINDSEY VONN

Actual JOURNAVX Patient, World Champion Skier

 

 

JOURNAVX is a nonopioid medication used to treat moderate-to-severe acute pain, including postoperative pain, in adults. JOURNAVX works by reducing pain signals before they reach the brain.

 

 

Lindsey Vonn is a paid spokesperson. Sponsored by Vertex Pharmaceuticals.

Results may vary.

 

 

“I took JOURNAVX for acute pain after my Achilles surgery.”

JAYSON TATUM

Actual JOURNAVX Patient, Basketball Champion

 

 

JOURNAVX is a nonopioid medication used to treat moderate-to-severe acute pain, including postoperative pain, in adults. JOURNAVX works by reducing pain signals before they reach the brain.

 

 

Jayson Tatum is a paid spokesperson. Sponsored by Vertex Pharmaceuticals.

Results may vary.

 

Download the JOURNAVX ®  Savings Card

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Savings Card

Watch JOURNAVX
Patient Stories

Apart from Lindsey Vonn and Jayson Tatum, images used in this website do not portray actual patients and healthcare providers, unless otherwise specified.

Interested in talking to a healthcare provider about your moderate-to-severe acute pain now?

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Discover JOURNAVX—a nonopioid prescription medicine for adults with moderate-to-severe acute pain, including postoperative paina

 

 

a Acute pain is a type of pain that starts suddenly and lasts less than 3 months. It’s often caused by an injury or surgery.

a Acute pain is a type of pain that starts suddenly and lasts less than 3 months. It’s often caused by an injury or surgery.

a Acute pain is a type of pain that starts suddenly and lasts less than 3 months. It’s often caused by an injury or surgery.

JOURNAVX is a different way to treat moderate-to-severe acute pain

JOURNAVX is a different way to treat moderate-to-severe acute pain

JOURNAVX is a different way to treat moderate-to-severe acute pain

Have questions
about JOURNAVX?

Get answers to common questions about JOURNAVX.

Read frequently
asked questions

Read frequently
asked questions

Read frequently
asked questions

The science behind
JOURNAVX

Learn how JOURNAVX reduces pain signals before they reach the brain.

See how it works

Savings and
support

We have programs to help eligible patients reduce costs for JOURNAVX.

Learn about the programs
JOURNAVX STORIES

 

Hear what real JOURNAVX patients have to say, including basketball champion Jayson Tatum

“JOURNAVX helped to reduce my acute pain after I had surgery to repair my ruptured Achilles.”

 

—Jayson Tatum, Basketball Champion

In clinical studies, JOURNAVX showed better pain reduction than placebo (sugar pill).

Explore now

If you were prescribed JOURNAVX, we want to hear from you. Tell us about your moderate-to-severe acute pain experience and you could be featured.

 

If you were prescribed JOURNAVX, we want to hear from you. Tell us about your moderate-to-severe acute pain experience and you could be featured.

If you were prescribed JOURNAVX, we want to hear from you. Tell us about your moderate-to-severe acute pain experience and you could be featured.

Get started now

RECURSOS

Recursos en Español

¿Es usted hispanohablante? Obtenga todo lo que necesita saber sobre JOURNAVX aquí.

Recursos en Español

TELL US

What is most important to you when it comes to moderate-to-severe acute pain treatment?

What is most important to you when it comes to moderate-to-severe acute pain treatment?

What is most important to you when it comes to moderate-to-severe acute pain treatment?

Choose a response. Then we’ll direct you to
helpful information based on your answer.

Choose a response. Then we’ll direct you to helpful information based on your answer.

Choose a response. Then we’ll direct you to helpful information based on your answer.

WHAT'S NEXT

How JOURNAVX Works
Recursos en Español

INDICATION AND IMPORTANT SAFETY INFORMATION

COLLAPSE

What is JOURNAVX?

JOURNAVX is a prescription medicine used to treat adults with moderate-to-severe short-term (acute) pain, including postoperative pain.

It is not known if JOURNAVX is safe and effective in children.

IMPORTANT SAFETY INFORMATION

Do not take JOURNAVX if you take certain medicines that are strong inhibitors of an enzyme called CYP3A. Ask your healthcare provider if you are not sure.

Before taking JOURNAVX, tell your healthcare provider about all of your medical conditions, including if you:

What is JOURNAVX?

JOURNAVX is a prescription medicine used to treat adults with moderate-to-severe short-term (acute) pain, including postoperative pain.

It is not known if JOURNAVX is safe and effective in children.

IMPORTANT SAFETY INFORMATION

Do not take JOURNAVX if you take certain medicines that are strong inhibitors of an enzyme called CYP3A. Ask your healthcare provider if you are not sure.

Before taking JOURNAVX, tell your healthcare provider about all of your medical conditions, including if you:

  • have liver problems. People with liver problems may have an increased risk of getting side effects
  • are pregnant or plan to become pregnant. JOURNAVX may temporarily reduce the chance of females becoming pregnant while on treatment
  • are breastfeeding or planning to breastfeed

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Taking JOURNAVX with certain other medicines may affect the way JOURNAVX and the other medicines work and may increase your risk of side effects. Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure.

Especially tell your healthcare provider if you take:

  • hormonal birth control medicine (contraceptives) containing progestins other than levonorgestrel or norethindrone as they may not work as well during treatment with JOURNAVX. Use nonhormonal contraceptives such as condoms or other forms of hormonal birth control during treatment and for 28 days after you stop taking JOURNAVX
  • medicines that are substrates of the CYP3A enzyme as they may become less effective during treatment with JOURNAVX. Your healthcare provider may need to adjust the dose of your medicine when starting or stopping JOURNAVX

What should I avoid while taking JOURNAVX?

Do not take food or drink containing grapefruit during treatment with JOURNAVX.

What are the possible side effects of JOURNAVX?

The most common side effects for patients treated with JOURNAVX included itching, muscle spasms, increased blood level of creatine phosphokinase, and rash.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all of the possible side effects of JOURNAVX.

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Please see full Prescribing Information, including Patient Information, for JOURNAVX.

VXR-US-43-2600752 (v1.0) | 08/2026

  • have liver problems. People with liver problems may have an increased risk of getting side effects
  • are pregnant or plan to become pregnant. JOURNAVX may temporarily reduce the chance of females becoming pregnant while on treatment
  • are breastfeeding or planning to breastfeed

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Taking JOURNAVX with certain other medicines may affect the way JOURNAVX and the other medicines work and may increase your risk of side effects. Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure.

Especially tell your healthcare provider if you take:

  • hormonal birth control medicine (contraceptives) containing progestins other than levonorgestrel or norethindrone as they may not work as well during treatment with JOURNAVX. Use nonhormonal contraceptives such as condoms or other forms of hormonal birth control during treatment and for 28 days after you stop taking JOURNAVX
  • medicines that are substrates of the CYP3A enzyme as they may become less effective during treatment with JOURNAVX. Your healthcare provider may need to adjust the dose of your medicine when starting or stopping JOURNAVX

What should I avoid while taking JOURNAVX?

Do not take food or drink containing grapefruit during treatment with JOURNAVX.

What are the possible side effects of JOURNAVX?

The most common side effects for patients treated with JOURNAVX included itching, muscle spasms, increased blood level of creatine phosphokinase, and rash.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all of the possible side effects of JOURNAVX.

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Please see full Prescribing Information, including Patient Information, for JOURNAVX.

VXR-US-43-2600752 (v1.0) | 08/2026

What is JOURNAVX?

JOURNAVX is a prescription medicine used to treat adults with moderate-to-severe short-term (acute) pain, including postoperative pain.

It is not known if JOURNAVX is safe and effective in children.

IMPORTANT SAFETY INFORMATION

Do not take JOURNAVX if you take certain medicines that are strong inhibitors of an enzyme called CYP3A. Ask your healthcare provider if you are not sure.

Before taking JOURNAVX, tell your healthcare provider about all of your medical conditions, including if you:

  • have liver problems. People with liver problems may have an increased risk of getting side effects
  • are pregnant or plan to become pregnant. JOURNAVX may temporarily reduce the chance of females becoming pregnant while on treatment
  • are breastfeeding or planning to breastfeed

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Taking JOURNAVX with certain other medicines may affect the way JOURNAVX and the other medicines work and may increase your risk of side effects. Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure.

Especially tell your healthcare provider if you take:

  • hormonal birth control medicine (contraceptives) containing progestins other than levonorgestrel or norethindrone as they may not work as well during treatment with JOURNAVX. Use nonhormonal contraceptives such as condoms or other forms of hormonal birth control during treatment and for 28 days after you stop taking JOURNAVX
  • medicines that are substrates of the CYP3A enzyme as they may become less effective during treatment with JOURNAVX. Your healthcare provider may need to adjust the dose of your medicine when starting or stopping JOURNAVX

What should I avoid while taking JOURNAVX?

Do not take food or drink containing grapefruit during treatment with JOURNAVX.

What are the possible side effects of JOURNAVX?

The most common side effects for patients treated with JOURNAVX included itching, muscle spasms, increased blood level of creatine phosphokinase, and rash.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all of the possible side effects of JOURNAVX.

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Please see full Prescribing Information, including Patient Information, for JOURNAVX.

VXR-US-43-2600752 (v1.0) | 08/2026